The crash happened just before 11 a.m. on I-83 southbound between Exit 45 - Paxton St/Bass Pro Drive and Exit 44B - 17th Street, according to PennDOT.
All lanes remained closed as of 11:30 a.m.
The crash appears to involve a microbus or passenger van, based on the traffic cameras in the area.
There is no word on any injuries.
This is one of two crashes on I-83 on Friday morning. You can read about the other crash here.
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